This dialogue initiates several discussions of the practice of Right Effort on the Eightfold Path. During this talk, Peter described the classical rendering of the Four Noble Efforts, placed into the context of 21st century neuroscience. He quoted the statements of Dr. Dan Siegal, who describes the importance of integrating different neural pathways-emotional, cognitive and behavioral-in the process of transforming “energy into information”. Peter then described the characteristics of the five hindrances of classical Buddhist teachings in the context of neural “dys-integration” as a way to understand the nature of suffering. Next week’s planned dialogue focuses on revisiting the Buddhist precepts with contemporary terms such as “commitment”.